Understanding the Role of the Immune System in Improving Tissue Regeneration

The Forum on Regenerative Medicine of the National Academies of Sciences, Engineering, and Medicine convened a two-day virtual public workshop to address knowledge gaps in the understanding of promising approaches to manipulate the immune system and/or the regenerative medicine product to improve outcomes of tissue repair and regeneration in patients. The workshop, titled "Understanding the Role of the Immune System in Improving Tissue Regeneration," explored the role of the immune system in the success or failure of regenerative medicine therapies. Participants considered potential strategies to effectively "prepare" patients' immune systems to accept regenerative therapies and increase the likelihood of successful clinical outcomes and also discussed risks associated with modulating the immune system. This Proceedings of a Workshop highlights the presentations and discussions that occurred during the workshop.

Table of Contents

• Front Matter
• 1 Introduction
• 2 Tissue Homeostasis, Inflammation, and Repair
• 3 Lessons Learned from Immune Tolerance and Graft Acceptance
• 4 Engineering of Allogeneic Donor Cells for Acceptance by the Host's Immune System
• 5 Endogenous Regeneration and the Role of the Local Environment in Repair
• 6 Modulating the Host Immune System to Create a Pro-Regenerative Environment
• 7 Tools and Preclinical Models for Monitoring and Optimizing the Host's Pro-Regenerative Environment
• 8 Harnessing the Immune System to Improve Patient Outcomes
• References
• Appendix A: Workshop Agenda
• Appendix B: Speaker Biographical Sketches
• Appendix C: Statement of Task
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