Optical Probes in Biology

Jin Zhang editor Sohum Mehta editor Carsten Schultz editor

Format:Hardback

Publisher:Taylor & Francis Inc

Published:26th Jan '15

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Optical Probes in Biology cover

Optical probes, particularly the fluorescent varieties, enable researchers to observe cellular events in real time and with great spatial resolution. Optical Probes in Biology explores the diverse capabilities of these powerful and versatile tools and presents various approaches used to design, develop, and implement them.

The book examines the use of optical probes to detect and track numerous molecular processes in living cells, including GTPase and kinase activities, membrane lipids, voltage, metal ions, metabolic signals, RNA, and histone modifications. It critically reviews the different probe designs and delves into the strategies for developing new fluorescent protein varieties with enhanced capabilities. It also covers sophisticated imaging techniques and equipment, such as intensity and lifetime-based fluorescence microscopy methods, used to visualize and track optical probes.

In addition, the book goes beyond live-cell tracking to discuss the growing application of activity-based probes for performing pharmacological drug screening and probing molecular processes in living animals. It also discusses emerging techniques that are expanding optical probe-based approaches into new biological frontiers.

With contributions from top international scientists, this book offers a thorough overview of the latest optical probes in cell biology and biochemistry. Both newcomers and established researchers will discover how to incorporate state-of-the-art optical probes and fluorescence imaging into their research.

"… the editors of Optical Probes in Biology have successfully gathered the finest molecular tool crafters in this research field to provide readers with a comprehensive view of state-of-the-art developments and applications of optical probes. Additionally, the practical information discussed makes this book an invaluable reference guide to the scientific community to improve the process of proper probe selection. I highly recommend this book to every scientist considering employing optical probes to facilitate their investigations."
Microscopy & Microanalysis, 2015

"Among the wide range of techniques elucidated in this book are GTPase and kinase activities, membrane lipids, metal ions, metabolic signals and histone modifications. Relevant chapters are written by experts in their fields who collectively provide readers with the means for bringing state-of-the art optical probe technques into their research."

--K. Alan Shore, Bangor University, U.K.

ISBN: 9781466510111

Dimensions: unknown

Weight: 839g

511 pages